I think I may have solved latency issues with guitar sound. When I was experiencing latency issues with the guitar sound, I put the guitar signal through two BIAS FX plugins – one plugin in Reaper for sound to OBS Studio and the standalone plugin for the window to be sent to OBS. I have now stopped using the standalone to send the image screen to OBS and now just use the plugin via Reaper which has stopped the very bad latency issues in the previous video.

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